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1996-02-27
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Document 0072
DOCN M9630072
TI Immunological response in mice after long-term stimulation with cell
wall antigens from Brucella melitensis.
DT 9603
AU Galdiero M; Bentivoglio C; Nuzzo I; De Martino L; Molitierno M;
Carratelli CR; Dipartimento di Patologia, Facolta di Veterinaria,
Universita; degli Studi di Napoli Federico II, Italy.
SO Res Microbiol. 1995 Jul-Aug;146(6):507-15. Unique Identifier : AIDSLINE
MED/96099691
AB The continuous stimulation of the immune system using cell wall antigens
from Brucella melitensis was found to cause both quantitative and
qualitative changes in circulating lymphocyte populations in mice.
Animals were inoculated in the hind legs with antigens on alternate days
for varying lengths of time. During a two-month period, we saw a higher
number of circulating lymphocytes, with an increase in the number of
CD4+ cells (L3T4+) and B lymphocytes (I-Ad). After two months, a drop in
the overall number of circulating lymphocytes occurred, with a decrease
in CD4+ cells and an increase in CD8+ cells. During the first two
months, we observed a size increase in popliteal lymph nodes and an
elevated humoral response. The response then waned with the declining
CD4+ cells. In the first two months, the treated animals also showed an
in vitro response to two mitogens, concanavalin A and lipopolysaccharide
and to the cell wall fraction, after which the treated animals showed a
decreased response.
DE Animal Antibody Formation Antigens, Bacterial/*IMMUNOLOGY
B-Lymphocytes/*IMMUNOLOGY Brucella melitensis/*IMMUNOLOGY CD4-Positive
T-Lymphocytes/*IMMUNOLOGY CD8-Positive T-Lymphocytes/*IMMUNOLOGY
Fluorescent Antibody Technique Hypertrophy/PATHOLOGY Lymph
Nodes/IMMUNOLOGY/PATHOLOGY Lymphocyte Count Male Mice Mice, Inbred
BALB C Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).